Systemic inflammatory changes and their clinical implications following thoracic cancer surgery
Massimiliano Fornasiero1, Georgios Geropoulos1, Dimitrios Giannis2
1Department of Thoracic Surgery, University College London Hospitals, NHS Foundation Trust, London, UK.
Indian Journal of Thoracic and Cardiovascular Surgery
|September 2, 2022
Summary
Surgical trauma causes inflammation impacting healing and outcomes. Minimally invasive thoracic surgery alters this inflammatory response, improving patient recovery compared to open procedures.
Area of Science:
- Immunology
- Surgical Oncology
- Thoracic Surgery
Background:
- Surgical procedures invariably induce an inflammatory response, directly correlating with tissue damage.
- The initial inflammatory response significantly influences tissue regeneration, surgical outcomes, and systemic antibacterial defenses.
- In thoracic surgery, systemic changes in cytokines and cells affect postoperative outcomes.
Purpose of the Study:
- To review the primary systemic inflammatory changes in thoracic cancer surgery.
- To discuss the clinical significance of these inflammatory alterations.
Main Methods:
- Literature review focusing on systemic inflammatory responses in thoracic cancer surgery.
- Analysis of studies comparing open, video-assisted, and robotic-assisted thoracic surgery.
Main Results:
- Minimally invasive approaches (video-assisted and robotic-assisted thoracic surgery) demonstrate improved postoperative outcomes.
- These advanced techniques are associated with an altered systemic inflammatory response compared to open thoracic surgery.
Conclusions:
- Systemic inflammatory changes are critical in thoracic cancer surgery.
- Minimally invasive thoracic surgery offers potential benefits through modulation of the inflammatory response.
Keywords:
Inflammatory responseRobotic surgerySystemic inflammationThoracic surgeryVideo-assisted thoracoscopic surgeryMore Related Videos
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