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Updated: Aug 30, 2025
Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood
Published on: February 5, 2020
Long-term efficacy and safety of programmed death-1 (PD-1) antibody alone in relapsed/refractory human
Chaoyu Wang1, Fanlin Zhou2, Lingqian Zhang1
1Department of Hematology Oncology Chongqing University Cancer Hospital, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing China.
Abstract:
We report a young patient initially diagnosed with human immunodeficiency virus (HIV)-associated Hodgkin lymphoma (HL), and received six cycles of ABVD chemotherapy regimens and involvement field irradiation therapy. However, the disease progressed after two months later, and then received second line GDP regimen. Unfortunately, after five cycles of GDP, the patient progression disease (PD) again. The patient was then offered sintilimab alone. After 8 cycles, the patient received complete response (CR) and no 3/4 grade toxicity. Currently, at a follow-up period of four years, he is still alive with CR and no lymphoma-related symptoms. This case demonstrates the feasibility of sintilimab antibody in relapsed/refractory HIV-associated Hodgkin lymphoma.
