Related Experiment Video
Updated: Aug 30, 2025
08:41
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
2.9K
Graves' Disease Caused by SARS-CoV-2 Infection
Bruno Sousa1, Catarina Pestana Santos1, Ana Gonçalves Ferreira2
1Internal Medicine Department, Hospital Garcia de Orta, Almada, Lisbon, Portugal.
European Journal of Case Reports in Internal Medicine
|September 2, 2022
Summary
This case study suggests SARS-CoV-2 infection may trigger Graves
Area of Science:
- Endocrinology
- Immunology
- Infectious Diseases
Background:
- Graves' disease is an autoimmune hyperthyroidism caused by thyrotropin receptor antibodies (TRAbs).
- Systemic manifestations include goitre, dermatopathy, and orbitopathy.
- The SARS-CoV-2 virus has been linked to various autoimmune phenomena.
Purpose of the Study:
- To report a case of Graves' disease potentially induced by SARS-CoV-2 infection.
- To highlight the importance of considering Graves' disease in post-COVID-19 hyperthyroidism.
Main Methods:
- Case presentation of a 28-year-old male with symptoms of hyperthyroidism post-mild SARS-CoV-2 infection.
- Laboratory investigations including thyroid function tests and TRAb levels.
- Diagnostic imaging: thyroid ultrasound and scintigraphy.
Main Results:
- The patient presented with fatigue, shortness of breath, palpitations, and goitre.
- Hyperthyroidism with elevated TRAbs was confirmed.
- Thyroid ultrasound showed a heterogeneous gland; scintigraphy confirmed Graves' disease pattern.
Conclusions:
- Graves' disease may be induced by SARS-CoV-2 infection via an autoimmune pathway.
- The patient achieved symptom resolution and thyroid function normalization with methimazole treatment.
- Graves' disease is a crucial differential diagnosis for hyperthyroidism following COVID-19.
Related Concept Videos
01:29Autoimmune Disorders
629
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
629
01:03Rous Sarcoma Virus (RSV) and Cancer
5.3K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.3K
01:17Gastritis-II: Pathophysiology
492
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
492
01:21Myocarditis I: Introduction
23
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
23
01:23Rheumatic Heart Disease I: Introduction
33
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
33
01:29Pulmonary Tuberculosis I
302
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
302