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Successful infusional 5-fluorouracil administration in a patient with vasospastic angina
Shannon Tai1, Divyanshu Mohananey2, Claire Griffiths3
1Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Abstract:
A 48-year-old female with metastatic colon adenocarcinoma and history of pre-existing coronary vasospasm with ventricular tachycardia (VT) successfully tolerated de novo 5-fluorouracil (5-FU) chemotherapy infusions with prophylactic administration and optimization of anti-spasm medications. 5-FU has been reported to produce severe cardiotoxic side effects, including coronary vasospasm, ventricular arrhythmias, and sudden cardiac death, and is not typically reported in individuals with pre-existing coronary vasospasm.
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