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Risperidone-induced priapism: a case report and literature review
Sarra Ateb1, Taoufik Fourati2, Hammadi Ben Rejeb2
1Établissement Public de Santé de Ville-Evrard (Pôle 93G03), 5 Rue Du Docteur Delafontaine 93200 Saint-Denis, France.
Therapeutic Advances in Psychopharmacology
|September 2, 2022
Summary
Priapism, a persistent erection, can be a side effect of antipsychotics like risperidone. Switching to olanzapine may resolve this rare but serious condition.
Area of Science:
- Neuroscience
- Pharmacology
- Urology
Background:
- Priapism is a prolonged, painful erection unrelated to sexual activity.
- Antipsychotic medications, particularly risperidone, are implicated as a cause of priapism.
- The mechanism involves alpha-adrenergic blockage in penile corpora cavernosa.
Observation:
- This paper details a case of risperidone-induced priapism.
- The condition resolved after switching to olanzapine.
- Literature review identified 43 cases of risperidone-associated priapism up to 2021.
Findings:
- Risperidone-induced priapism is not dose-dependent.
- Concurrent medication use can occasionally precipitate priapism.
- Switching antipsychotics after priapism induction presents challenges due to varying alpha-blocking properties.
Implications:
- Careful patient screening for priapism risk factors before prescribing antipsychotics is crucial.
- Patients must be informed about the potential for priapism and the need for immediate medical attention.
- Further research is needed to establish optimal alternative antipsychotic choices.
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