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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
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Related Experiment Video

Updated: Aug 30, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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The Plausible Relationship Between Periodontitis and Glaucoma.

Kamakshi Gupta1, Navneet Kaur2, Gurpreet Kaur1

  • 1Department of Periodontics, National Dental College and Hospital, Derabassi, Mohali, IND.

Cureus
|September 2, 2022
PubMed
Summary
This summary is machine-generated.

Periodontitis, an oral infection, may contribute to systemic health issues, particularly inflammatory eye diseases. Research explores the link between oral dysbiosis and conditions like glaucoma and age-related macular degeneration.

Keywords:
diabetic retinopathyglaucomainflammationperiodontitisperiomedicineretinal ganglion cellsuveitis

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Area of Science:

  • Oral health and systemic disease research
  • Ophthalmology and periodontology
  • Inflammatory and infectious diseases

Background:

  • Periodontitis is linked to various systemic conditions, potentially sharing pathogenic mechanisms.
  • Advances in technology identify novel inflammatory mediators in chronic diseases associated with periodontitis.
  • Oral foci of infection are increasingly implicated in systemic morbidities, including chronic oral inflammation's role in eye diseases.

Purpose of the Study:

  • To explore the mechanistic understanding of the link between periodontal diseases and ocular comorbidities.
  • To review scientific evidence suggesting a relationship between glaucoma and periodontitis via common inflammatory pathways.
  • To focus on the role of oral dysbiosis in the progression of inflammatory eye diseases.

Main Methods:

  • Literature review focusing on periodontal-systemic disease associations.
  • Analysis of molecular biological techniques and their implications for understanding oral-ocular disease links.
  • Examination of inflammatory mediators and markers shared between periodontitis and eye conditions.

Main Results:

  • Limited scientific evidence currently suggests a direct relationship between glaucoma and periodontitis, though shared inflammatory pathways are proposed.
  • The concept of oral dysbiosis is highlighted as a potential factor in the pathogenesis of various inflammatory eye diseases.
  • Novel inflammatory mediators are being identified, offering potential support for periodontal-systemic disease associations.

Conclusions:

  • Further research is needed to elucidate the mechanistic link between periodontitis and ocular comorbidities.
  • Oral dysbiosis may play a significant role in the progression of inflammatory eye diseases.
  • Identifying shared inflammatory mediators could strengthen the understanding of periodontal-systemic disease connections.