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Bile acids in immunity: Bidirectional mediators between the host and the microbiota
Urszula Godlewska1, Edyta Bulanda1, Tomasz P Wypych1
1Laboratory of Host-Microbiota Interactions, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Frontiers in Immunology
|September 2, 2022
Summary
Bile acids are key mediators in the bidirectional host-microbiota dialogue, influencing microbial communities and host immunity. Harnessing bile acids offers a promising therapeutic strategy for intestinal inflammation.
Area of Science:
- Microbiology
- Immunology
- Gastroenterology
Background:
- Host-microbiota interactions are bidirectional, with implications for host immunity.
- Bile acids play a dual role in this interplay, acting as host-derived compounds and microbial metabolites.
Purpose of the Study:
- To provide a comprehensive overview of the mechanisms governing host-microbiota dialogue involving bile acids.
- To explore the therapeutic potential of bile acids in treating intestinal inflammation.
Main Methods:
- Literature review and synthesis of existing research on bile acid metabolism and function.
- Analysis of host-microbiota interactions and their impact on immune responses.
- Exploration of therapeutic strategies targeting bile acids for intestinal inflammation.
Main Results:
- Bile acids exert bacteriostatic effects, shaping microbial composition and survival.
- Microbiota-modified bile acids modulate host immunity and influence microbial communities.
- Bile acids are central to the bidirectional communication between the host and its microbiota.
Conclusions:
- Bile acids are critical regulators of the host-microbiota axis.
- Understanding bile acid functions provides insights into intestinal inflammation.
- Targeting bile acids presents a novel therapeutic avenue for inflammatory conditions.
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