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Effect of Vitamin D Supplementation on Inflammatory Biomarkers in School-Aged Children with Attention Deficit

Mahsa Samadi1, Fatemeh Gholami1, Marzieh Seyedi1

  • 1Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

International Journal of Clinical Practice
|September 2, 2022
PubMed

Insights

Vitamin D supplementation did not reduce inflammatory cytokines in children with Attention Deficit Hyperactivity Disorder (ADHD). This 3-month trial found no significant changes in Interleukin-6 or Tumor Necrosis Factor-alpha levels.

Area of Science:

  • Pediatric Neurology
  • Nutritional Immunology
  • Psychiatry

Background:

  • Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder.
  • Inflammatory processes are increasingly implicated in the pathophysiology of ADHD.
  • Vitamin D deficiency is prevalent in children with ADHD, suggesting a potential role for supplementation.

Purpose of the Study:

  • To investigate the efficacy of vitamin D3 supplementation in reducing serum levels of inflammatory cytokines (IL-6 and TNF-α) in children diagnosed with ADHD.
  • To assess the impact of vitamin D on serum 25(OH)D levels in this population.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial involving 75 school-aged children with ADHD (DSM-V criteria).
  • Participants received either 2000 IU/day of vitamin D3 or a placebo for 3 months.
  • Serum levels of 25(OH)D, IL-6, and TNF-α were measured pre- and post-intervention.

Main Results:

  • Vitamin D supplementation significantly increased serum 25(OH)D levels (P=0.01).
  • No significant differences in serum IL-6 and TNF-α were observed between the vitamin D and placebo groups at baseline or after the intervention.
  • The intervention did not demonstrate a reduction in key inflammatory markers.

Conclusions:

  • Three months of vitamin D3 supplementation (2000 IU/day) is not effective in reducing serum inflammatory cytokines in children with ADHD.
  • Further research is warranted to explore the relationship between vitamin D, inflammation, and ADHD, potentially with different dosages or durations.
  • The study highlights the need for continued investigation into adjunctive therapies for ADHD management.
Abstract

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