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Cyclosporin for treatment of refractory multisystemic inflammatory syndrome in a child

Luisa Berenise Gámez-González1, Hiromichi Hamada2, Marco Antonio Yamazaki-Nakashimada3

  • 1Allergy and Immunology Department, Hospital Infantil de Especialidades de Chihuahua, Chihuahua, Mexico.

Cardiology in the Young
|September 2, 2022
PubMed

Insights

Multisystemic inflammatory syndrome in children (MIS-C) is a severe condition following COVID-19. Cyclosporin-A offers a safe and effective alternative treatment for MIS-C cases resistant to standard therapies.

Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Immunology

Background:

  • Multisystemic inflammatory syndrome in children (MIS-C) is a rare but serious condition associated with SARS-CoV-2 infection.
  • It presents with multiorgan dysfunction, often weeks after the initial infection.

Observation:

  • A 12-year-old boy presented with gastrointestinal symptoms, shock, ventricular dysfunction, and pericardial effusion.
  • Initial treatment with intravenous immunoglobulins, corticosteroids, and tocilizumab was ineffective.

Findings:

  • The patient showed a positive response to cyclosporin-A treatment.
  • Cyclosporin-A, administered intravenously and orally, demonstrated safety and efficacy.

Implications:

  • Cyclosporin-A represents a promising therapeutic option for refractory MIS-C.
  • This finding expands treatment strategies for severe pediatric inflammatory conditions post-COVID-19.

Keywords:
COVID-19Kawasaki diseaseMIS-CSARS-CoV2cyclosporine

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