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Related Experiment Video

Updated: Aug 30, 2025

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

Implementation strategy for complete pathogen reduction technology treated apheresis platelet inventory.

Elaine Shu¹, Concepcion Dela Cruz Batilo¹, Harry Sussmann¹

¹Stanford Blood Center, Stanford Health Care, Stanford, California, USA.

|September 2, 2022

Summary

This summary is machine-generated.

Transitioning to full pathogen reduction technology (PRT) for platelets is feasible. A pilot study demonstrated no adverse effects on platelet production, suggesting potential for improved net margins.

Keywords:

platelet transfusion statistics study design

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Last Updated: Aug 30, 2025

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

Routine Screening Method for Microparticles in Platelet Transfusions

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Published on: January 31, 2018

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Published on: August 24, 2015

Area of Science:

Transfusion Medicine
Blood Banking
Microbiology

Background:

Bacterial contamination in platelet products is a significant public health issue.
The US Food and Drug Administration recommends bacterial contamination mitigation strategies.
Pathogen reduction technology (PRT) has proven effective in Europe.

Purpose of the Study:

To evaluate the feasibility of transitioning from a dual bacterial culturing (BacT) and PRT system to a full PRT inventory.
To assess the impact of full PRT implementation on platelet production metrics.

Main Methods:

A one-month pilot study was conducted to simulate 100% PRT conditions.
Key platelet production metrics were collected for four months pre- and post-implementation.
Data on split rate, product yield, collection types, and discard rate were analyzed.

Main Results:

No significant differences were observed in split rate, low-yield product proportion, or collection type proportions during the pilot.
An 11-minute increase in average double collection duration was noted.
Post-implementation monitoring showed no changes in split rate, discard rate, or low-yield unit metrics.
Statistical differences were found in the proportion of single, double, and triple collections, and average yield of full dose products.

Conclusions:

Transitioning to a full PRT inventory can be achieved without negatively impacting platelet production.
Pilot studies are valuable for predicting the effects of implementing full PRT.
This approach may lead to increased net margins for blood centers.