Related Experiment Video

Updated: Aug 30, 2025

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

30.6K

Factors related to ultrafiltration volume with icodextrin dialysate use in children

Naoaki Mikami1, Riku Hamada2,3, Ryoko Harada1

  • 1Department of Nephrology, Tokyo Metropolitan Children's Medical Center, Fuchu, Tokyo, Japan.

Pediatric Nephrology (Berlin, Germany)
|September 2, 2022
PubMed

Insights

Icodextrin peritoneal dialysis offers superior water removal in children, especially with adequate dwell time and volume. This osmotic agent is more effective than glucose for pediatric patients requiring peritoneal dialysis.

Area of Science:

  • Nephrology
  • Pediatric Dialysis
  • Peritoneal Transport

Background:

  • Icodextrin peritoneal dialysate shows lower absorption and higher ultrafiltration than glucose in high-permeability patients.
  • Limited data exist on icodextrin dialysate use in pediatric populations.

Purpose of the Study:

  • To analyze factors influencing ultrafiltration volume with icodextrin dialysate in pediatric patients.
  • To compare ultrafiltration volumes between icodextrin and glucose dialysates in children.

Main Methods:

  • Retrospective analysis of pediatric patients undergoing peritoneal equilibration tests and dialysis with icodextrin.
  • Statistical analysis of factors affecting ultrafiltration volume with icodextrin.
  • Comparison of ultrafiltration volumes between icodextrin and medium-concentration glucose dialysates in the same patients.

Main Results:

  • Dwell time, D/P-creatinine, D/D0-glucose, age, height, and weight correlated with icodextrin ultrafiltration volume.
  • Dwell volumes ≥ 550 mL/m² significantly increased ultrafiltration.
  • Icodextrin demonstrated superior ultrafiltration and longer dwell times compared to glucose dialysate.

Conclusions:

  • Icodextrin ultrafiltration volume is reduced in pediatric patients with small stature.
  • Adequate dwell time and volume are crucial for maximizing water removal in children using icodextrin.
  • Icodextrin offers superior ultrafiltration compared to medium-concentration glucose for extended dwell times in pediatric peritoneal dialysis.
Abstract

Keywords:
ChildrenIcodextrinKidney replacement therapyPeritoneal dialysis

More Related Videos

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol07:59

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol

Published on: July 28, 2018

11.3K
Image Acquisition Method for the Sonographic Assessment of the Inferior Vena Cava06:59

Image Acquisition Method for the Sonographic Assessment of the Inferior Vena Cava

Published on: January 13, 2023

3.7K

Related Concept Videos

Peritoneal Dialysis I: Introduction and Procedure01:30

Peritoneal Dialysis I: Introduction and Procedure

Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
156
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
122
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
42
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
163
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
783
Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
121