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Blood pressure and kidney function in neonates and young infants with intrauterine growth restriction

Katharina Monika Heuchel1, Fabian Ebach2, Ebru Aileen Alsat2

  • 1Faculty of Medicine, University Bonn, Bonn, Germany.

Pediatric Nephrology (Berlin, Germany)
|September 2, 2022
PubMed

Insights

Intrauterine growth restriction (IUGR) did not show differences in blood pressure or urinary protein excretion in neonates. However, IUGR infants had lower serum creatinine and blood urea nitrogen levels.

Area of Science:

  • Neonatal Medicine
  • Pediatric Nephrology
  • Developmental Biology

Background:

  • Intrauterine growth restriction (IUGR) is linked to adult hypertension and kidney damage.
  • IUGR affects kidney anatomy, nephrogenesis, and vascular development.

Purpose of the Study:

  • To compare clinical and metabolic parameters in IUGR versus non-IUGR neonates.
  • To assess early postnatal indicators of kidney health in IUGR infants.

Main Methods:

  • 39 IUGR and 60 non-IUGR neonates were studied over 18 months.
  • Compared blood pressure, serum creatinine (SCr), BUN, and urinary protein excretion.
  • Urinary markers were normalized to urine creatinine levels.

Main Results:

  • No significant differences in blood pressure or urinary protein excretion were found.
  • Serum creatinine and BUN levels were lower in the IUGR group.
  • These findings suggest potential differences in liver and muscle mass.

Conclusions:

  • Current routine biomarkers do not predict future hypertension or kidney issues in IUGR infants.
  • Further research is necessary for early postnatal prediction of adverse outcomes in IUGR.
  • Early detection and management strategies for IUGR-related complications require further investigation.
Abstract

Keywords:
Blood pressureIntrauterine growth restrictionKidney functionNeonatesProteinuria

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