Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

2.8K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply to the Letter to the Editor: Late gadolinium enhancement synthesis from cardiac cine MRI: physical, methodological, and editorial considerations.

European radiology·2026
Same author

The effect of aromatherapy on postoperative nausea and vomiting: a systematic review and meta-analysis.

Annals of medicine and surgery (2012)·2026
Same author

PRRC2A-mediated m<sup>6</sup>A modification on NCOA4 promotes thymic epithelial tumor progression through PKM2-induced glycolysis.

Cell death & disease·2026
Same author

PEG-GE11-modified nanoplatform for co-delivery of cisplatin and plumbagin in targeted therapy of oral squamous cell carcinoma.

RSC advances·2026
Same author

Global Trends and Research Hotspots of Ferroptosis in Osteoarthritis: A Bibliometric and Visualized Study (2012-2026).

The Journal of craniofacial surgery·2026
Same author

[Potential mechanism of <i>Peiyuan Fumai</i> decoction() in regulating P-selectin/ P-selectin glycoprotein ligand-1 pathway for prevention and treatment of thrombosis after total knee arthroplasty].

Zhongguo gu shang = China journal of orthopaedics and traumatology·2026

Related Experiment Video

Updated: Aug 30, 2025

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
09:17

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

413

Extracellular Vesicles in Tissue Engineering: Biology and Engineered Strategy.

Ziyin Pan1,2, Weiyan Sun1,2, Yi Chen1,2

  • 1Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School Of Medicine, Shanghai, 200092, China.

Advanced Healthcare Materials
|September 2, 2022
PubMed
Summary

Extracellular vesicles (EVs) are key for tissue engineering (TE) due to their role in cell communication. Bioactive biomaterials enhance EV delivery for improved regenerative therapies.

Keywords:
bioactive materialsengineered strategiesextracellular vesiclessurface modificationtissue engineering

More Related Videos

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics
08:50

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Published on: August 16, 2024

838
Characterizing Extracellular Vesicles from Biological Fluids
05:07

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

493

Related Experiment Videos

Last Updated: Aug 30, 2025

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
09:17

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

413
Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics
08:50

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Published on: August 16, 2024

838
Characterizing Extracellular Vesicles from Biological Fluids
05:07

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

493

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cell Biology

Background:

  • Extracellular vesicles (EVs) are crucial for intercellular communication via paracrine signaling.
  • These nanosized particles (30-140 nm) are increasingly utilized in tissue engineering (TE).
  • Bioactive biomaterials can serve as carriers to improve EV retention and controlled release.

Purpose of the Study:

  • To review the biological characteristics and therapeutic potential of EVs in tissue regeneration.
  • To explore the design of EV-loaded biomaterials for enhanced regenerative therapies.
  • To highlight engineered strategies for overcoming limitations of natural EVs in clinical applications.

Main Methods:

  • Review of current literature on extracellular vesicles and biomaterials in tissue engineering.
  • Analysis of EV characteristics, including their functional components (nucleic acids, proteins, lipids).
  • Discussion of various design principles for EV-loaded biomaterial systems.

Main Results:

  • EVs demonstrate direct impacts on target cells and indirect effects on angiogenesis and immune modulation.
  • Specific functional components within EVs drive their therapeutic outcomes.
  • EV-loaded biomaterials offer enhanced delivery and controlled release, improving therapeutic efficiency.
  • Engineered strategies can address challenges like EV heterogeneity, targeting, yield, and scalability.

Conclusions:

  • EVs hold significant promise for tissue engineering applications.
  • Optimized biomaterial carriers and engineered EVs are essential for maximizing therapeutic potential.
  • Further development of EV-based strategies is crucial for clinical translation in regenerative medicine.