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Children with 16p11.2 deletions or duplications show significant sensory processing differences. These differences impact daily life, similar to those seen in autistic children.

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Area of Science:

  • Genetics
  • Neurodevelopmental Disorders
  • Sensory Processing

Background:

  • 16p11.2 deletions and duplications are linked to various neurodevelopmental issues.
  • Sensory processing in these cohorts has not been previously detailed.

Purpose of the Study:

  • To investigate sensory processing differences in children with 16p11.2 chromosomal variations.
  • To assess the impact of these sensory differences on daily functioning.

Main Methods:

  • Parents/caregivers of 38 children with 16p11.2 deletion and 31 with 16p11.2 duplication completed sensory questionnaires (SBQ, CSP-2).
  • Additional assessments included autistic traits (SRS-2), ADHD traits (Conners 3), anxiety (SCAS-P), and adaptive behavior (VABS-3).

Main Results:

  • Both 16p11.2 deletion and duplication groups exhibited clear sensory processing differences.
  • Sensory behaviors were more frequent and impactful compared to neurotypical children, resembling those in autistic children.
  • Over 70% showed differences in sensory registration; high percentages of duplication group were unusually sensitive or avoidant of stimuli.

Conclusions:

  • Sensory processing differences are prevalent and significantly impact children with 16p11.2 deletions and duplications.
  • This study provides the first detailed assessment of sensory processing in these populations.
  • Understanding these sensory challenges is crucial for clinical management and support.