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Updated: Aug 30, 2025
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Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
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Idiopathic upper extremity deep vein thrombosis: A systematic review
Hiu Lam Agnes Yuen1,2, Ee Tan1, Huyen Tran2
1Monash Haematology, Monash Health, Melbourne, Victoria, Australia.
European Journal of Haematology
|September 2, 2022
Summary
Management of idiopathic upper extremity deep vein thrombosis (UEDVT) lacks robust evidence. Current studies do not compare anticoagulation alone versus additional interventions, highlighting the need for prospective research.
Area of Science:
- Vascular Medicine
- Thrombosis Research
- Evidence-Based Medicine
Background:
- Idiopathic upper extremity deep vein thrombosis (UEDVT) management remains controversial.
- Treatment options range from anticoagulation alone to thrombolysis or decompressive surgery.
Purpose of the Study:
- To systematically review the effects of anticoagulation alone versus anticoagulation with additional interventions for idiopathic UEDVT.
- To assess the incidence of recurrent UEDVT and post-thrombotic syndrome (PTS).
Main Methods:
- Systematic search for studies on acute UEDVT treatment (within 4 weeks of onset).
- Inclusion criteria: >=10 subjects, 6-12 months anticoagulation, >=6 month follow-up.
- Primary outcomes: recurrent UEDVT, PTS. Secondary outcomes: VTE, bleeding, mortality.
Main Results:
- Seven studies reported recurrent UEDVT rates (0-12% with anticoagulation alone, 0-23% with additional interventions).
- Five studies reported PTS rates (4-32% without severe PTS).
- No studies directly compared anticoagulation alone to additional interventions; heterogeneity and bias were noted.
Conclusions:
- Limited evidence supports current idiopathic UEDVT management strategies.
- Prospective comparative studies are crucial for definitive treatment guidelines.
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