Development and validation of prognostic nomograms in patients with ascending type of nasopharyngeal carcinoma:
Kai-Hua Chen1, Yu-Ting Jiang1, Rong Zhao1
1Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, China.
Background:
Nomograms specifically used to predict the prognosis of ascending type nasopharyngeal carcinoma (NPC) have not been constructed.
Methods:
Data of ascending type (T3-4N0-1M0) NPC from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2015 were extracted.
Results:
Altogether 862 patients with ascending type NPC were enrolled, including 603 in training cohort and 259 in validation cohort. Age, marital status, pathology, grade, tumor size, T classification, and chemotherapy were the independent prognostic factors for overall survival (OS). Age, marital status, pathology, grade, and chemotherapy were the independent prognostic factors for cancer-specific survival (CSS). In training cohort, the concordance index of the OS and CSS nomograms were 0.694 (95% confidence interval [CI], 0.677-0.711) and 0.678 (95%CI, 0.659-0.697), respectively, while those in validation cohort were 0.740 (95%CI, 0.715-0.765) and 0.708 (95%CI, 0.679-0.737), separately.
Conclusion:
The as-constructed nomograms for ascending type NPC could provide accurate prognostic predictions of OS and CSS.
