Retrospective record review on timing of COVID-19 vaccination and cardiac surgery
Jacky Y K Ho1, Ivan C H Siu1, Karen H L Ng1
1Division of Cardiothoracic Surgery, Department of Surgery, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.
Insights
COVID-19 vaccination is safe for cardiac surgery patients, with minimal adverse effects and no deaths. A 3-6 month post-surgery window is recommended for vaccination, guiding future booster programs.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- The coronavirus disease 2019 (COVID-19) pandemic presents unique challenges for cardiac surgery.
- Limited evidence exists regarding COVID-19 vaccination safety and timing in patients undergoing cardiac surgery.
- Understanding vaccination timing and adverse effects is crucial for patient counseling.
Purpose of the Study:
- To evaluate the safety and outcomes of COVID-19 vaccination in adult patients following major cardiac surgery.
- To determine the optimal timing for COVID-19 vaccination in this patient population.
- To assess the incidence of vaccination-related adverse effects and complications.
Main Methods:
- A single-center, retrospective observational study included adult cardiac surgery patients from January 2021 to December 2021.
- Data collected included postoperative clinical outcomes, COVID-19 vaccination status (Sinovac or Pfizer), and adverse events.
- Vaccination timing relative to surgery was analyzed.
Main Results:
- Out of 426 patients, 52% received at least one COVID-19 vaccine dose.
- 15% were vaccinated before surgery, and 36% after surgery, with a mean post-operative first dose at 216 days.
- Only 1.4% of patients experienced vaccination-related complications, and no vaccine-related mortality was observed.
Conclusions:
- COVID-19 vaccination is safe for patients post-major cardiac surgery, demonstrating a low rate of adverse effects and no associated mortality.
- A recommended vaccination timeframe of 3-6 months after cardiac surgery provides a reasonable guideline.
- These findings can inform future COVID-19 vaccination strategies and booster programs for cardiac surgical patients.
Background:
Novel clinical challenges are faced by cardiac surgeons under the coronavirus disease 2019 (COVID-19) pandemic. Amidst the uncertainties faced due to the socioeconomic and public health impact, there is little evidence surrounding COVID-19 vaccination in patients undergoing cardiac surgery. Timing of vaccination and postvaccination adverse effects are required parameters to discuss with cardiac surgical patients.
Methods:
This is a single-center, retrospective observational study. All patients who underwent adult cardiac surgery at the Prince of Wales Hospital, Hong Kong from January 2021 to December 2021 were included. Postoperative clinical outcomes, COVID-19 vaccination status, and vaccination-related adverse effects were collected.
Results:
A total of 426 patients; 117 (27%) underwent isolated coronary artery bypass grafting, 111 (26%) underwent valvular surgery, and 97 (23%) underwent aortic surgery. Patients received either Sinovac CoronaVac or Pfizer BNT162b2 vaccine. Overall vaccination rate with at least 1 dose was 52% (n = 212), 15% (n = 63) received the first dose before surgery, 36% (n = 149) received the first dose vaccination after surgery. Rate of completion with second and third doses of vaccination were 22% (n = 89) and 4.9% (n = 20), respectively. The mean timing of first dose of vaccine after surgery was 216 ± 84 days from operation. Three (1.4%) patients recorded vaccination-related complications.
Conclusions:
COVID-19 vaccination is safe in patients who received major cardiac surgery, with low adverse effects recorded and no vaccine-related mortality observed. A time frame of 3-6 months after cardiac surgery receiving COVID-19 vaccination is reasonable and could serve as a guidance for future COVID-19 vaccination booster programs.
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