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Severe anemia, anorexia, and uremia associated with diabetic foot infections: A case series

Jennifer L Den1, Lindsey M Gay2, Neal R Barshes3

  • 1Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.

Foot (Edinburgh, Scotland)
|September 2, 2022
PubMed

Insights

Severe anemia and metabolic derangements can occur in diabetic foot infections, contrary to typical mild cases. This case series highlights extreme presentations requiring significant medical intervention.

Area of Science:

  • Endocrinology
  • Hematology
  • Infectious Diseases

Background:

  • Anemia of inflammation is common in chronic diseases like diabetes.
  • Diabetic foot infections often present with mild, self-limited anemia.
  • Severe anemia and metabolic complications are not typically associated with these infections.

Purpose of the Study:

  • To report four cases of diabetic foot infections with severe anemia.
  • To describe associated metabolic derangements and significant weight loss.

Main Methods:

  • Case series presentation.
  • Review of patient medical records.
  • Analysis of laboratory values and clinical outcomes.

Main Results:

  • Four patients with diabetic foot infections experienced severe anemia (hemoglobin <8 g/dL) requiring blood transfusions.
  • Patients also exhibited significant weight loss (>30 pounds), hyponatremia, hypoalbuminemia, and uremia.
  • These findings represent an atypical and severe presentation of anemia of inflammation in diabetic foot infections.

Conclusions:

  • Diabetic foot infections can, in rare instances, lead to severe anemia and profound metabolic disturbances.
  • These severe cases necessitate aggressive management beyond typical treatment protocols.
  • Further research is warranted to understand the mechanisms behind these extreme presentations.
Keywords:
Diabetic foot infectionInflammationSepsis

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