Status of neurological deficits after mechanical thrombectomy in elderly patients with ischemia
Ichiro Deguchi1, Takashi Osada1, Shinya Kohyama2
1Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center, Saitama, Japan.
Background:
Numerous studies report poorer outcomes after mechanical thrombectomy (MT) in elderly patients than in non-elderly patients. We aimed to investigate the changes in neurological symptoms after MT in elderly patients.
Methods:
We included 151 patients with acute stroke who independently performed activities of daily living before admission, underwent MT at our hospital between January 1, 2019 and December 31, 2021, and had successful recanalization (thrombolysis in cerebral infarction grade >2b). The subjects were divided into two groups according to whether they were aged ≥80 years (elderly group) or <80 years (non-elderly group), and the National Institutes of Health Stroke Scale (NIHSS) scores and deep and subcortical white matter hyperintensity (DSWMH) grades were compared between both groups.
Results:
There were 57 (38 %) and 94 (62 %) patients in the elderly and non-elderly groups, respectively. After propensity score matching, the median (interquartile range) NIHSS scores were significantly higher in the elderly group than in the non-elderly group at both 24 h (12 [5.5-19] vs 8; [2-14] P = 0.040) and 1 week (8 [3-12] vs 2.5 [0-13.5]; P = 0.041) after MT but not before MT (18 [13.5-22.5] vs 20 [14.5-24]; P = 0.549). DSWMH grades were significantly higher in the elderly group than in the non-elderly group (2 [1-3] vs 1 [0-2]; P = 0.018).
Conclusions:
MT in the elderly group was associated with poorer improvement in neurological symptoms from the early period after MT than in the non-elderly group, even when successful recanalization was achieved. White matter lesions may contribute to the poor neurological improvement after recanalization in the elderly group.
