Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conditioned Taste Aversion01:14

Conditioned Taste Aversion

219
Conditioned taste aversion, also known as sauce béarnaise syndrome, is a phenomenon in which an individual develops an aversion to a certain food taste following a negative experience, typically illness. This form of aversion is a type of classical conditioning in which the taste of the food (conditioned stimulus, CS) is associated with the experience of illness (unconditioned stimulus, UCS).
A notable characteristic of conditioned taste aversion is that it often requires only a single...
219
The Physiology of Taste01:24

The Physiology of Taste

4.2K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
4.2K
Gustation01:43

Gustation

48.6K
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
48.6K
Taste Buds and Receptors01:20

Taste Buds and Receptors

2.6K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
2.6K
Classical Conditioning in Daily Life01:17

Classical Conditioning in Daily Life

977
Classical conditioning, a fundamental principle of associative learning, explains various phenomena observed in daily life, such as fear development, the placebo effect, taste aversion, and drug habituation. These applications demonstrate the profound impact of associative learning on human behavior and physiological responses.
John B. Watson and Rosalie Rayner famously demonstrated the development of fear through classical conditioning in their experiment with Little Albert. They paired the...
977
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

250
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
250

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Individual differences in behavioral effects of xylazine and opioid-xylazine mixtures in male rats.

Psychopharmacology·2025
Same author

Development of Squaramides as Allosteric Modulators of the CB<sub>1</sub> Receptor: Synthesis, Computational Studies, Biological Characterization, and Effects against Cocaine-Induced Behavioral Sensitization and Reinstatement in Rats.

Journal of medicinal chemistry·2025
Same author

The imidazoline I<sub>2</sub> receptor agonist 2-BFI reduces abuse-related effects of morphine: self-administration and drug discrimination.

Psychopharmacology·2023
Same author

Distinct Effects of Methamphetamine Isomers on Limbic Norepinephrine and Dopamine Transmission in the Rat Brain.

ACS chemical neuroscience·2023
Same author

Functional and Genetic Characterization of Porcine Beige Adipocytes.

Cells·2022
Same author

The <i>SLC27A1</i> Gene and Its Enriched PPAR Pathway Are Involved in the Regulation of Flavor Compound Hexanal Content in Chinese Native Chickens.

Genes·2022

Related Experiment Video

Updated: Aug 30, 2025

Taste Exam: A Brief and Validated Test
07:10

Taste Exam: A Brief and Validated Test

Published on: August 17, 2018

16.5K

Selective TAAR1 agonists induce conditioned taste aversion.

Jianfeng Liu1,2, Ruyan Wu2, Bernard Johnson2

  • 1School of Pharmacy, Nantong University, Nantong, 226001, Jiangsu Province, China.

Psychopharmacology
|September 2, 2022
PubMed
Summary

Selective trace amine-associated receptor 1 (TAAR1) agonists, proposed for mental disorders, can cause conditioned taste aversion (CTA). This suggests TAAR1 activation may produce aversive effects, requiring careful clinical evaluation.

Keywords:
Conditioned taste aversionNaClRO5166017RO5263397SaccharinTAAR1

More Related Videos

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
08:07

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Published on: August 24, 2016

9.1K
How to Create Conditioned Taste Aversion for Grazing Ground Covers in Woody Crops with Small Ruminants
05:55

How to Create Conditioned Taste Aversion for Grazing Ground Covers in Woody Crops with Small Ruminants

Published on: April 30, 2016

7.4K

Related Experiment Videos

Last Updated: Aug 30, 2025

Taste Exam: A Brief and Validated Test
07:10

Taste Exam: A Brief and Validated Test

Published on: August 17, 2018

16.5K
Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
08:07

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Published on: August 24, 2016

9.1K
How to Create Conditioned Taste Aversion for Grazing Ground Covers in Woody Crops with Small Ruminants
05:55

How to Create Conditioned Taste Aversion for Grazing Ground Covers in Woody Crops with Small Ruminants

Published on: April 30, 2016

7.4K

Area of Science:

  • Neuropharmacology
  • Behavioral Neuroscience

Background:

  • Trace amine-associated receptor 1 (TAAR1) is implicated in neuropsychiatric disorders.
  • TAAR1 agonists show therapeutic potential for schizophrenia and addiction.
  • Aversive effects of TAAR1 agonists are largely unknown.

Purpose of the Study:

  • To investigate if selective TAAR1 agonists RO5166017 and RO5263397 induce conditioned taste aversion (CTA).

Main Methods:

  • Rats were administered selective TAAR1 full agonist RO5166017 and partial agonist RO5263397.
  • Conditioned taste aversion (CTA) was assessed using saccharin and NaCl taste novelty.
  • Experiments included wild-type, TAAR1 heterozygous knockout (taar1±), and homozygous knockout (taar1-/-) rats.

Main Results:

  • Both RO5166017 and RO5263397 induced significant aversions to saccharin and NaCl taste novelty.
  • RO5166017 induced CTA in wild-type and taar1± rats, but not in taar1-/- rats.
  • TAAR1 activation was sufficient for the taste-aversive properties of RO5166017.

Conclusions:

  • Selective TAAR1 agonists can produce robust conditioned taste aversion (CTA).
  • These findings highlight the potential aversive effects of TAAR1 agonists.
  • Further evaluation of TAAR1 agonist aversive properties is crucial before clinical application.