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"Role of kidney function and concentrations of BAFF, sPD-L1 and sCD25 on mortality in hospitalized patients with

Ladan Mansouri1, Senka Sendic2, Sebastian Havervall3

  • 1Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden. Ladan.Mansouri@ki.se.

BMC Nephrology
|September 2, 2022
PubMed

Insights

Chronic kidney disease patients face higher COVID-19 mortality. Key immune factors like BAFF and sCD25, not just kidney function, predict COVID-19 death risk.

Area of Science:

  • Immunology
  • Nephrology
  • Virology

Background:

  • Chronic kidney disease (CKD) is a known risk factor for severe COVID-19 outcomes.
  • Understanding the interplay between kidney function, immune response, and COVID-19 mortality is crucial.

Purpose of the Study:

  • To investigate the association between kidney function, T and B lymphocyte modulatory factors, and mortality risk in COVID-19 patients.
  • To identify specific immune markers that predict mortality in COVID-19.

Main Methods:

  • Analysis of in-hospital and 30-day mortality in 110 COVID-19 patients.
  • Measurement of plasma levels of T and B cell modulators (e.g., BAFF, sCD25, sPD-L1).
  • Subgroup analysis comparing COVID-19 patients with CKD patients and healthy controls.

Main Results:

  • Higher BAFF and sCD25 plasma levels were observed in non-survivors.
  • Elevated BAFF, sCD25, and sPD-L1 levels correlated with increased in-hospital and 30-day mortality risk.
  • Kidney function (eGFR) was not directly associated with mortality risk in logistic regression models.

Conclusions:

  • Kidney function and specific immune modulators (BAFF, sCD25, PD-L1) are associated with COVID-19 mortality, independent of traditional risk factors.
  • These findings highlight the role of the adaptive immune system in COVID-19 prognosis.
  • Further research into these immune modulators may reveal new prognostic and therapeutic strategies for COVID-19.
Abstract

Keywords:
BAFFCOVID-19Kidney functionSPD-L1sCD25

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