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Strengthening Mental Abilities with Relational Training (SMART) in multiple sclerosis (MS): study protocol for a
Nima Golijani-Moghaddam1, David L Dawson2, Nikos Evangelou3
1School of Psychology, University of Lincoln, Sarah Swift Building, Brayford Pool, Lincoln, LN6 7TS, UK. nmoghaddam@lincoln.ac.uk.
This study explored the feasibility of the SMART online cognitive rehabilitation program for multiple sclerosis (MS) patients. The program aims to improve cognitive function and daily task completion in individuals with MS.
Area of Science:
- Neuroscience
- Rehabilitation Medicine
- Clinical Trials
Background:
- Multiple sclerosis (MS) is a central nervous system condition affecting 1 in 600 UK individuals, with 130 new diagnoses weekly.
- Up to 70% of people with MS experience cognitive deficits impacting daily life, work, and independence.
- Effective cognitive interventions are a research priority to reduce the burden of MS on individuals and healthcare services.
Purpose of the Study:
- To conduct a feasibility study for the novel online cognitive rehabilitation program for MS (SMART).
- To inform the development of a definitive trial for the SMART program.
- To develop a framework for cost-effectiveness analysis and assess the signal of efficacy.
Main Methods:
- Feasibility study design to inform a definitive trial.
- Development of a cost-effectiveness analysis framework.
- Exploratory assessment of the signal of efficacy for the SMART program.
Main Results:
- Feasibility study outcomes are pending, with results intended to guide a definitive trial.
- A framework for cost-effectiveness analysis will be developed.
- Exploratory analysis will provide an initial signal of the SMART program's efficacy.
Conclusions:
- This feasibility trial is a necessary precursor to a definitive trial for the SMART program.
- Positive outcomes could lead to a clinically and cost-effective intervention, improving MS cognitive rehabilitation.
- The SMART program has the potential to enhance service delivery and optimize support for individuals with MS.
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