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Fractures: Bone Repair

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...

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Fracture Risk in Pediatric Patients With MEN2B.

Iris Li¹, Iris R Hartley², Joanna Klubo-Gwiedzdzinska³

¹Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

The Journal of Clinical Endocrinology and Metabolism

|September 3, 2022

Summary

This summary is machine-generated.

Patients with multiple endocrine neoplasia type 2B (MEN2B) have a higher fracture risk in childhood than healthy peers. This study highlights increased fracture occurrence and less common fracture sites in MEN2B patients.

Keywords:

MEN2B fracture pediatric

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Area of Science:

Endocrinology
Pediatric Oncology
Skeletal Biology

Background:

The skeletal phenotype in multiple endocrine neoplasia type 2B (MEN2B) is known, but fracture risk remains unevaluated.
MEN2B is a rare genetic disorder associated with specific mutations.

Purpose of the Study:

To determine the fracture risk in patients diagnosed with MEN2B.
To compare fracture incidence in MEN2B patients with general pediatric populations.

Main Methods:

A retrospective case series with chart review was conducted.
Data from 48 MEN2B patients (ages 5-36) at the National Institutes of Health were analyzed, including medical records, imaging, and lab results up to age 19.

Main Results:

Twenty out of 48 (41.7%) MEN2B patients experienced at least one fracture, with most occurring by age 19.
The fracture frequency in childhood (0-19 years) was 38%, significantly higher than reported rates in healthy US pediatric cohorts.
Less common fractures, such as vertebral compression and pelvic fractures, were observed.

Conclusions:

Patients with MEN2B exhibit an elevated risk of fractures compared to the general pediatric population.
The occurrence of less common fracture sites suggests a potential impact of the activating RET mutation on bone physiology.
Further research is warranted to understand the underlying mechanisms affecting bone health in MEN2B.