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Inpatient Zoledronic Acid and Integrated Orthopedic and Fracture Liaison Services Improve Osteoporosis Treatment
WuQiang Fan1, Melissa Machado1, Benjamin Z Leder1
1Massachusetts General Hospital, Boston, MA 02114, USA.
The Journal of Clinical Endocrinology and Metabolism
|September 3, 2022
Summary
Implementing a Fracture Liaison Service (FLS) and inpatient zoledronic acid (ZA) significantly improved osteoporosis pharmacotherapy rates in fragility fracture patients, enhancing secondary fracture prevention.
Area of Science:
- Orthopedics
- Geriatrics
- Pharmacology
Background:
- Fragility fractures lead to increased morbidity and mortality.
- Osteoporosis pharmacotherapy is underutilized for secondary fracture prevention.
Purpose of the Study:
- To enhance the rate of pharmacotherapy for secondary prevention of osteoporotic fractures in patients with fragility fractures.
Main Methods:
- An observational, single-center study involving patients with fragility fractures admitted to Massachusetts General Hospital.
- Integration of a Fracture Liaison Service (FLS) with orthopedic services.
- Systematic consultation of FLS for fragility fracture patients.
- Administration of zoledronic acid (ZA) during hospitalization for high-risk patients.
Main Results:
- The pharmacotherapy rate increased to 70% from a baseline of 8-11% with FLS and inpatient ZA.
- Inpatient ZA administration did not impact average length of stay or 30-day readmission rates.
- Treatment status remained unknown for 37.9% of patients.
Conclusions:
- Integrating FLS with orthopedic services and utilizing inpatient ZA administration improves osteoporosis pharmacotherapy rates.
- This approach benefits patients with fragility fractures who face barriers to outpatient follow-up.
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