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Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

Breast neurofibroma: A case report.

F Watik¹, M Harrad¹, Z Sami¹

¹Gynecology Department, Univesity Hospital Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Morocco.

International Journal of Surgery Case Reports

|September 3, 2022

Summary

This summary is machine-generated.

Neurofibromatosis type 1 (Von Recklinghausen disease) can manifest as rare breast neurofibromas. Early diagnosis and management are crucial due to potential malignant transformation risks.

Keywords:

Anatomopathology Breast Neoplasms Neurofibroma Neurofibromatosis Radiology

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Area of Science:

Oncology
Genetics
Pathology

Background:

Neurofibromatosis type 1 (Von Recklinghausen disease) is a rare, autosomal dominant genetic disorder.
It presents with significant clinical variability, even within families.
Total penetrance is a characteristic feature of the condition.

Observation:

A case report details a 40-year-old woman with Von Recklinghausen disease.
The patient discovered a breast nodule through self-examination.
The neurofibroma's location in the breast is exceptionally rare.

Findings:

Anatomopathological examination confirmed the diagnosis of neurofibroma.
Breast involvement in neurofibromatosis is documented as extremely rare but possible.
Biopsy-exeresis was performed for diagnosis and management.

Implications:

Prompt and appropriate patient management is essential for early diagnosis.
Timely intervention in Von Recklinghausen disease is critical.
Awareness of potential malignant transformation necessitates vigilant monitoring and treatment.