Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inhaled Medications

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Overnight Oxygenation and Patient Comfort Using a New Nasal Cannula Versus Standard Cannula in Long-Term Oxygen Therapy.

Respiratory care·2026

Same author

Automated administration of medical oxygen using model predictive control incorporating real-time monitoring of breathing parameters.

Computers in biology and medicine·2026

Same author

Regional Extrathoracic Deposition of Inhaled Epinephrine in an Idealized Child Airway: Influence of Pressurized Metered Dose Inhaler Actuator Orifice Diameter.

Pharmaceutical research·2026

Same author

E-liquid flavor alters nicotine exposure, puff topography, and subjective effects under <i>ad libitum</i> use conditions.

Addictive behaviors reports·2026

Same author

Voice-Calling Detection Distance with a Parabolic Microphone in Land Search and Rescue.

Wilderness & environmental medicine·2025

Same author

Spray-Drying Process Optimization and Modeling for an Inhaled Dry Powder of 5-Azacytidine for Treating Local and Metastatic Lung Cancer.

Molecular pharmaceutics·2025

Search research articles

Related Experiment Video

Updated: Aug 29, 2025

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

Characterization of dry powder inhaler performance through experimental methods.

Conor A Ruzycki¹, Scott Tavernini², Andrew R Martin²

¹Lovelace Biomedical, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA.

Advanced Drug Delivery Reviews

|September 4, 2022

Summary

This review explores in vitro testing methods for dry powder inhalers (DPIs), focusing on improving in vitro-in vivo correlations for better quality control and novel device development.

Keywords:

Aerodynamic particle size distributions Compendial testing Extrathoracic deposition Fine particle dose In vitro-in vivo correlation Intersubject deposition variability Optical methods Thoracic deposition Tracheobronchial filter

More Related Videos

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Intratracheal Administration of Dry Powder Formulation in Mice

Intratracheal Administration of Dry Powder Formulation in Mice

Published on: July 25, 2020

Related Experiment Videos

Last Updated: Aug 29, 2025

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Intratracheal Administration of Dry Powder Formulation in Mice

Intratracheal Administration of Dry Powder Formulation in Mice

Published on: July 25, 2020

Area of Science:

Pharmaceutical Technology
Inhalation Drug Delivery
Biomedical Engineering

Background:

Dry powder inhalers (DPIs) require robust quality control and development methods.
In vitro testing is crucial for predicting in vivo performance of DPIs.

Purpose of the Study:

To review the current state of in vitro testing methods for DPIs.
To focus on developing accurate in vitro-in vivo correlations.
To identify future research directions for DPI characterization.

Main Methods:

Review of compendial testing methods for DPIs.
Analysis of flow profiles and their impact on DPI performance.
Characterization of extrathoracic and regional thoracic deposition.
Evaluation of methods for bolus delivery timing, environmental influences, and electrostatic charge.

Main Results:

Current in vitro methods are essential for DPI quality control and early-stage development.
Accurate in vitro-in vivo correlations remain a key challenge.
Various factors like flow, geometry, environment, and charge influence DPI performance.

Conclusions:

Advanced in vitro methods are vital for optimizing DPI formulation and device design.
Future research should focus on deposition variability, compendial method refinement, and clinically relevant testing.
Novel tracheobronchial filters may offer improved in vitro performance measures.