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[Feasibility analysis of CT angiography derived computational fluid dynamics in evaluating intracranial artery
1Department of Diagnostic Radiology, Jinling Clinical Hospital of Nanjing Medical University/PLA General Hospital of Eastern Theater Command, Nanjing 210002, China.
Insights
Noninvasive hemodynamic analysis using CT angiography (CTA) can accurately assess intracranial artery stenosis significance. This method offers a viable alternative to invasive fractional flow reserve (FFR) assessments.
Area of Science:
- Neurology
- Medical Imaging
- Biomedical Engineering
Background:
- Intracranial artery stenosis poses a significant risk for stroke.
- Accurate assessment of stenosis severity is crucial for treatment decisions.
- Invasive fractional flow reserve (FFR) is the gold standard but carries risks.
Purpose of the Study:
- To evaluate the feasibility of noninvasive hemodynamic analysis using CT angiography (CTA) for assessing intracranial artery stenosis.
- To compare CT-derived fractional flow reserve (CT-FFR) with invasive FFR measurements.
Main Methods:
- Retrospective study of 8 patients with intracranial artery stenosis.
- 3D intracranial artery models were created from CTA data.
- Computational fluid dynamics (CFD) were used to calculate hemodynamic parameters and CT-FFR.
- Comparison with invasive FFR measurements.
Main Results:
- CT-FFR values (0.59±0.18) closely correlated with invasive FFR values (0.60±0.22).
- Noninvasive hemodynamic analysis demonstrated high feasibility.
Conclusions:
- Noninvasive hemodynamic analysis based on CTA is a promising tool for evaluating the physiological significance of intracranial arterial stenosis.
- This approach may reduce the need for invasive procedures.
Abstract:
A retrospective study was performed on 8 patients, including 7 males and 1 female, aged 47 to 77 (59±3) years, with intracranial artery stenosis in General Hospital of Eastern Theater Command from November 2018 to May 2019, who underwent CT angiography (CTA), digital subtraction angiography (DSA) and invasive fractional flow reserve (FFR) assessment. Three-dimensional (3D) prototyping models of intracranial artery based on image data of CTA was constructed and the hemodynamic parameters were obtained using computational fluid dynamics methods. The results showed that CT-FFR value was 0.59±0.18, and invasive FFR value was 0.60±0.22, from which we propased that noninvasive hemodynamic analyses can be used to evaluate the physiological significance of intracranial arterial stenosis.
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