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Related Experiment Videos

[Pneumococci resistant to penicillin].

F A Moraga Llop, J Sarto, O del Valle

    Anales Espanoles De Pediatria
    |April 1, 1987
    PubMed
    Summary
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    Penicillin-resistant Streptococcus pneumoniae strains were identified in 23.9% of cases studied. Vancomycin and rifampin showed high activity against these resistant pneumococci.

    Area of Science:

    • Medical Microbiology
    • Infectious Diseases
    • Antimicrobial Resistance

    Context:

    • Between January 1983 and December 1984, a study investigated pneumococcal isolates.
    • Penicillin resistance in Streptococcus pneumoniae was a significant clinical concern during this period.

    Purpose:

    • To determine the prevalence of penicillin-resistant pneumococci.
    • To evaluate the in vitro activity of various antibiotics against resistant strains.

    Summary:

    • Out of 46 studied strains, 11 (23.9%) exhibited penicillin resistance, with 4.3% showing total resistance.
    • Pneumococcal disease was confirmed via blood cultures (7 cases) and cerebrospinal fluid (CSF) cultures (4 cases).
    • Diagnoses included sepsis, bacteremia, pneumonia, meningitis, and ventriculitis, particularly in immunosuppressed patients.

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    Impact:

    • Vancomycin and rifampin demonstrated the highest activity against the isolated resistant strains.
    • Third-generation cephalosporins (cefotaxime, ceftriaxone) and cefuroxime showed good in vitro activity and CSF penetration, suggesting potential therapeutic options for meningitis and ventriculitis.