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Olfaction01:25

Olfaction

44.8K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
44.8K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

9.5K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.5K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

9.2K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
9.2K

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Related Experiment Video

Updated: Aug 29, 2025

Simple and Computer-assisted Olfactory Testing for Mice
06:40

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

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Olfactory Dysfunction in Schizophrenia: Evaluating Olfactory Abilities Across Species.

Taitum O Cothren1, Christopher J Evonko1, David A MacQueen2

  • 1Department of Psychology, University of North Carolina at Wilmington, Wilmington, NC, USA.

Current Topics in Behavioral Neurosciences
|September 4, 2022
PubMed
Summary

Olfactory dysfunction, or impaired sense of smell, is a profound symptom in schizophrenia, impacting daily life and social interactions. Research is advancing to understand these deficits for early detection and new treatments.

Keywords:
Odor discriminationOdor identificationOdor memoryOdor sensitivityOdor thresholdOlfactionSchizophrenia

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Sensory Science

Background:

  • Olfactory dysfunction is a common yet understudied symptom in schizophrenia.
  • Deficits in smell are more global and profound in schizophrenia compared to other psychiatric disorders.
  • These impairments affect food enjoyment, hazard detection, and social relationships.

Conclusions:

  • Olfactory deficits are a key feature of schizophrenia with significant real-world consequences.
  • Understanding these deficits can lead to improved early detection and novel therapeutic strategies.
  • Cross-species research is crucial for elucidating the neurobiology of olfactory dysfunction in schizophrenia and psychosis.