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Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
Published on: September 28, 2018
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Adjunctive neuronavigated accelerated continuous theta-burst stimulation in obsessive-compulsive disorder: a
Aniruddha Mukherjee1, Pramod Kumar Kumre2, Nishant Goyal1
1Centre for Cognitive Neuroscience, Central Institute of Psychiatry, Ranchi, India.
CNS Spectrums
|September 5, 2022
Summary
Accelerated robotized neuronavigated continuous theta burst stimulation (cTBS) over the supplementary motor area (SMA) significantly improved obsessive-compulsive disorder (OCD) symptoms and associated depression. This novel treatment offers a promising alternative for patients resistant to standard therapies.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Technology
Background:
- Obsessive-compulsive disorder (OCD) affects 40% of patients unresponsive to standard treatments, necessitating novel therapeutic approaches.
- Continuous theta burst stimulation (cTBS), a form of repetitive transcranial magnetic stimulation, offers rapid and sustained effects on synaptic plasticity.
- Limited research exists on cTBS efficacy at the supplementary motor area (SMA) for OCD.
Purpose of the Study:
- To evaluate the effectiveness of accelerated robotized neuronavigated cTBS targeting the SMA in patients diagnosed with OCD.
Main Methods:
- 32 OCD patients were randomized into active and sham cTBS groups.
- An accelerated protocol involved 2 daily sessions of 900 pulses for 3 weeks (30 sessions total).
- Assessments included Yale-Brown Obsessive-Compulsive Rating Scale (YBOCS), CGI, HAM-D, and HAM-A at baseline, week 3, and week 8.
Main Results:
- 26 patients completed the study.
- The active cTBS group demonstrated significant improvements in YBOCS obsession, compulsion, and total scores compared to the sham group.
- Significant improvements were also observed in CGI-S, CGI-C, and HAM-D scores for the active cTBS group.
Conclusions:
- Adjunctive accelerated cTBS over the SMA shows significant efficacy in improving OCD psychopathology, illness severity, and depression.
- Further research with larger cohorts is warranted to confirm these findings and expand knowledge on this treatment modality.
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