Related Experiment Video
Updated: Aug 29, 2025
05:10
Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
321
Colon Cancer and Obesity: A Narrative Review
Shrimahitha Duraiyarasan1, Mayowa Adefuye2, Nisha Manjunatha3
1Research, K.A.P. Viswanatham Government Medical College, Tiruchirappalli, IND.
Cureus
|September 5, 2022
Summary
Obesity significantly increases colorectal cancer (CRC) risk by altering hormones and inflammatory markers. Weight loss, exercise, and screening using BMI and waist circumference are crucial for obese individuals to reduce CRC incidence.
Area of Science:
- Oncology
- Metabolic Syndrome
- Gastroenterology
Background:
- Obesity is a critical factor in the development of various cancers, notably colorectal cancer (CRC).
- Obesity influences metabolic and inflammatory pathways implicated in carcinogenesis.
- Hormonal imbalances and altered gut microbiota in obesity contribute to CRC pathogenesis.
Purpose of the Study:
- To review the pathophysiological associations between obesity and colorectal cancer development.
- To highlight the role of obesity-related factors in CRC initiation and progression.
Main Methods:
- Literature review on obesity and its link to colorectal cancer.
- Analysis of key molecular and physiological mechanisms involved.
Main Results:
- Obesity elevates insulin, IGF-1, leptin, resistin, IL-6, TNF-α, and MCP-1, promoting colonic cell proliferation.
- Reduced levels of inhibitory hormones like ghrelin and adiponectin in obese individuals increase CRC risk.
- Obesity-induced gut dysbiosis can favor carcinogenic processes.
Conclusions:
- Obesity is a significant risk factor for CRC through multiple biological pathways.
- Lifestyle modifications including weight loss and physical activity are recommended for CRC prevention in obese populations.
- Screening for CRC in obese individuals, using BMI and waist circumference for risk assessment, is advised.
Keywords:
colorectal cancer (crc)estrogen and crcghrelin and crcobesity and cancerobesity and inflammatory markersobesity and mutationoxidative dna damageresistin and cancerrole of gut microbiomes in cancerrole of obesity and diabetesMore Related Videos
Related Concept Videos
01:24Obesity
593
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
593
02:59Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K
01:21Barrett Esophagus-II: Clinical Manifestations and Management
281
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
281
01:17Chronic Bowel Disorders: Introduction
527
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
527
03:03mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
398
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
398