The Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response

Area of Science:

• Cardiovascular Biology
• Immunology
• Cell Signaling

Background:

• The Hippo pathway, including YAP (yes-associated protein), is crucial for tissue growth and cardiovascular development.
• Emerging research links the Hippo-YAP pathway to inflammation and immune responses, with complex roles in the cardiovascular system.
• Understanding these mechanisms is vital for addressing cardiovascular diseases (CVDs).

Purpose of the Study:

• To review the function and mechanisms of the Hippo-YAP pathway in cardiovascular diseases (CVDs) over the past decade.
• To emphasize the pathway's role in regulating inflammatory cell infiltration and cytokine activation in CVDs.
• To clarify the mechanisms underlying tissue inflammation and immune response in the cardiovascular system.

Main Methods:

• Literature review of studies published in the last decade.
• Focus on research investigating the Hippo-YAP pathway in cardiovascular contexts.
• Analysis of findings related to inflammation, immune response, and specific CVDs.

Main Results:

• The Hippo-YAP pathway influences cardiovascular development, regeneration, and remodeling.
• The pathway plays a significant, though context-dependent, role in cardiovascular inflammation.
• Evidence suggests involvement in inflammatory cell infiltration and cytokine activation in conditions like myocardial infarction, cardiomyopathy, and atherosclerosis.

Conclusions:

• The Hippo-YAP pathway is a key player in cardiovascular inflammation and immune responses.
• Further research is needed to fully elucidate the mechanisms by which the Hippo-YAP pathway regulates inflammation in CVDs.
• Targeting the Hippo-YAP pathway may offer novel therapeutic strategies for cardiovascular diseases.