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Updated: Aug 29, 2025

Application of MassSQUIRM for Quantitative Measurements of Lysine Demethylase Activity
07:02

Application of MassSQUIRM for Quantitative Measurements of Lysine Demethylase Activity

Published on: March 11, 2012

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Mechanisms of carcinogenic activity triggered by lysine-specific demethylase 1A

Chao Yang1, Dan Li2, Shaohong Zang1

  • 1National Engineering Research Center for Marine Aquaculture, Institute of Innovation and Application, Zhejiang Ocean University, Zhoushan, China.

Frontiers in Pharmacology
|September 5, 2022
PubMed

Insights

Lysine-specific demethylase 1A (LSD1) is a key epigenetic regulator in cancer. Targeting LSD1 offers a promising strategy for developing novel anticancer therapies by disrupting oncogenic mechanisms.

Area of Science:

  • Epigenetics
  • Cancer Biology
  • Molecular Oncology

Background:

  • Epigenetics is crucial in cancer research.
  • Lysine-specific demethylase 1A (LSD1) is the first identified histone demethylase.
  • LSD1 regulates gene transcription via demethylation of H3K4 and H3K9.

Purpose of the Study:

  • To summarize the oncogenic mechanisms driven by LSD1.
  • To highlight LSD1 as a potential therapeutic target in cancer.
  • To provide insights for developing novel anticancer strategies targeting LSD1.

Main Methods:

  • Literature review of epigenetic mechanisms in cancer.
  • Analysis of LSD1's role in various cancer processes.
  • Summary of LSD1's interactions with regulatory factors.

Main Results:

  • Abnormal LSD1 expression is observed in multiple cancers.
  • LSD1 influences cancer proliferation, apoptosis, metastasis, invasion, and drug resistance.
  • LSD1 interacts with various regulatory factors to mediate oncogenesis.

Conclusions:

  • LSD1 plays a significant role in cancer development and progression.
  • Targeting LSD1 presents a viable therapeutic avenue for cancer treatment.
  • Further research into LSD1-mediated mechanisms can inform effective anticancer drug development.
Keywords:
LSD1anticancer activitydemethylationepigeneticshistone modificationslysine methylationsignaling pathwaytargets

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