Related Experiment Video
Updated: Aug 29, 2025

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
Published on: January 19, 2024
Relationship of anemia with COVID-19 deaths: A retrospective cross-sectional study
Manish Jha1, M L Tak1, Rashmi Gupta1
1Department of Anesthesia, Dr. S. N. Medical College and Associated Hospitals, Jodhpur, Rajasthan, India.
Insights
Anemia significantly correlates with COVID-19 severity and mortality. Hemoglobin levels can serve as a prognostic marker for risk stratification in patients with COVID-19.
Area of Science:
- Medical Research
- Clinical Medicine
- Public Health
Background:
- The second wave of COVID-19 in India resulted in substantial mortality.
- Investigating factors influencing COVID-19 severity is crucial for patient management.
Purpose of the Study:
- To determine the impact of anemia on COVID-19 severity.
- To evaluate hemoglobin (Hb) as a prognostic marker for disease severity.
Main Methods:
- Retrospective analysis of 784 patients admitted to a COVID adult intensive care unit (ICU).
- Anemia classification based on World Health Organization (WHO) guidelines.
- Statistical analysis using the Chi-squared test to assess the relationship between anemia and mortality.
Main Results:
- Out of 784 patients, 507 died from COVID-19.
- Nearly half (49.3%) of deceased patients had anemia.
- Anemia showed a significant correlation with COVID-19 death in both males and females, and in patients with no other comorbidities.
Conclusions:
- Anemia is an independent prognostic risk factor for COVID-19 severity.
- Hemoglobin concentration can be utilized for risk stratification in COVID-19 patients.
- Anemia management may be important in mitigating COVID-19 outcomes.
Background And Aims:
With the second wave of COVID-19, India lost close to three lakh people within the span of a few months. In this study, we aimed to investigate the impact of anemia on the severity of COVID-19 based on the hemoglobin (Hb) concentration of the patients noted at the time of admission to the intensive care unit (ICU), to mark Hb as a prognostic marker of disease severity for the future.
Material And Methods:
Retrospective data was collected from 784 patients admitted to the COVID adult ICU between March and June 2021. Patients were identified as anemic and non-anemic based on the World Health Organization (WHO) guidelines. Chi-squared test was applied to see the relationship of anemia with the patient deaths.
Results:
Among the 784 patients, 507 succumbed to COVID-19. Of these, 49.3% had varying degrees of anemia. Significant correlation of anemia with death due to COVID-19 was found in males and females (P = 0.002106 and P = 0.033071, respectively) and in patients without any other comorbidities except anemia (P = 0.002020). This suggests that anemia is independently an important parameter that plays a role in severity of COVID-19.
Conclusion:
Upon observing a significant correlation between anemia and COVID-19 severity, it can be stated that anemia should be considered as an independent prognostic risk factor for COVID-19 and that hemoglobin can be used for risk stratification in patients under home or hospital care.
More Related Videos
Related Concept Videos
Bias in Epidemiological Studies
Disorders of Erythrocytes
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
The Periodic Table and Organismal Elements
Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Confounding in Epidemiological Studies

