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Updated: Aug 29, 2025

Scale-up Chemical Synthesis of Thermally-activated Delayed Fluorescence Emitters Based on the Dibenzothiophene-S,S-Dioxide Core
Published on: October 24, 2017
Green methodologies for the synthesis of 2-aminothiophene
Valentin Duvauchelle1, Patrick Meffre1, Zohra Benfodda1
1CHROME Laboratory, University of Nîmes, Rue du Dr. G. Salan, 30021 Nîmes Cedex 1, France.
Abstract:
Pollution and the rising energy demand have prompted the design of new synthetic reactions that meet the principles of green chemistry. In particular, alternative synthesis of 2-aminothiophene have recently focused interest because 2-aminothiophene is a unique 5-membered S-heterocycle and a pharmacophore providing antiprotozoal, antiproliferative, antiviral, antibacterial or antifungal properties. Here, we review new synthetic routes to 2-aminothiophenes, including multicomponent reactions, homogeneously- or heterogeneously-catalyzed reactions, with focus on green pathways.
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