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Ocular surface microbiota: Ophthalmic infectious disease and probiotics
Ming-Cheng Chiang1, Edward Chern1,2
1niChe Lab for Stem Cell and Regenerative Medicine, Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan.
Frontiers in Microbiology
|September 5, 2022
Summary
The ocular surface microbiota (OSM) and gut microbiome influence eye health. This review explores the gut-eye axis and probiotics for ophthalmic infections.
Area of Science:
- Microbiology
- Ophthalmology
- Immunology
Background:
- Commensal bacteria in various human body sites are increasingly recognized for their health importance.
- Ocular surface microbiota (OSM) research is expanding due to advancements in DNA sequencing technologies.
Purpose of the Study:
- To review the current understanding and investigation of ocular surface microbiota.
- To introduce the novel concept of the gut-eye axis.
- To examine the link between ophthalmic infectious diseases and alterations in OSM or gut microbiota.
Main Methods:
- Literature review of current studies.
- Analysis of research on ocular surface microbiota.
- Exploration of the gut-eye axis concept.
Main Results:
- Emerging evidence highlights the significance of OSM in ocular health.
- Alterations in OSM and gut microbiota are associated with ophthalmic infectious diseases.
- The gut-eye axis represents a new paradigm in understanding this relationship.
Conclusions:
- The gut-eye axis offers a new perspective on ophthalmic infectious diseases.
- Probiotics show potential for treating ophthalmic infections but have limitations.
- Further research is needed to explore the therapeutic applications of probiotics in ophthalmology.
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