Related Experiment Video

Updated: Aug 29, 2025

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

5.2K

Evaluation of Crocin Effect on Contrast-Induced Nephropathy Following Coronary Angiography or Angioplasty: A

Lida Shojaei1, Shima Esfandiary1, Mohammad Rouzbahani2

  • 1Department of Clinical Pharmacy, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Iranian Journal of Pharmaceutical Research : IJPR
|September 5, 2022
PubMed

Insights

Crocin effectively prevents contrast-induced nephropathy (CIN) in chronic kidney disease patients undergoing angiography. This study found significantly lower CIN incidence with crocin compared to standard hydration alone.

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Contrast-induced nephropathy (CIN) is a significant cause of hospital-acquired acute kidney injury.
  • Current prophylactic strategies for CIN, primarily antioxidant therapy and hydration, show limited efficacy.
  • Chronic kidney disease (CKD) patients are at high risk for CIN following contrast media exposure.

Purpose of the Study:

  • To evaluate the efficacy of crocin as a prophylactic agent against CIN in CKD patients undergoing coronary angiography/angioplasty.
  • To assess the impact of crocin on serum creatinine and urinary NGAL levels post-contrast media exposure.
  • To determine the incidence of CIN in CKD patients treated with crocin versus standard care.

Main Methods:

  • A randomized clinical trial involving 110 CKD stage 3 patients undergoing coronary angiography/angioplasty.
  • Patients received standard hydration; the intervention group received 30 mg oral crocin doses for three consecutive days.
  • CIN incidence was defined by serum creatinine increase (≥ 0.3 mg/dL) or urinary NGAL changes within 48 hours of contrast media exposure.

Main Results:

  • No significant increase in serum creatinine was observed in the crocin group within 48 hours of the procedure.
  • Urinary NGAL levels showed no significant changes in either the crocin or control group.
  • CIN incidence was significantly lower in the crocin group (1.75%) compared to the control group (13.2%; P = 0.028).

Conclusions:

  • Crocin administration demonstrates a significant nephron-protective role in preventing CIN in CKD patients.
  • Crocin represents a promising therapeutic strategy to reduce CIN incidence in at-risk patient populations.
  • Further research may explore optimal dosing and long-term effects of crocin for CIN prevention.

Keywords:
Acute Kidney InjuryAngiographyContrast-Induced NephropathyCrocinNGAL

More Related Videos

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy07:40

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Published on: May 26, 2023

1.3K
Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration07:59

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration

Published on: April 4, 2022

1.4K

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
54
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
134
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
50
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
24
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
64
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
21