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The role of protein kinase C in diabetic microvascular complications

Deng Pan1,2,3, Lin Xu4, Ming Guo1,2

  • 1Xiyuan hospital of China Academy of Chinese Medical Sciences, Beijing, China.

Frontiers in Endocrinology
|September 5, 2022
PubMed

Insights

Protein kinase C (PKC) activation contributes to diabetic microvascular complications by increasing oxidative stress. This review details PKC

Area of Science:

  • Biochemistry and Molecular Biology
  • Endocrinology
  • Cardiovascular Research

Background:

  • Diabetic microvascular complications are a major cause of morbidity.
  • Protein kinase C (PKC) activation is implicated in these complications.
  • High glucose conditions activate PKC, leading to oxidative stress.

Purpose of the Study:

  • To review the role of PKC in diabetic microvascular complications.
  • To present experimental and clinical evidence linking PKC to disease development.

Main Methods:

  • Literature review of experimental studies.
  • Analysis of clinical trial data.
  • Focus on PKC signaling pathways in microvasculature.

Main Results:

  • PKC activation under hyperglycemia stimulates redox reactions and oxidative stress.
  • This leads to microvascular dysfunction, including altered blood flow, permeability, and structural changes.
  • Evidence supports PKC's role in angiogenesis and extracellular matrix accumulation.

Conclusions:

  • PKC is a key mediator in the pathogenesis of diabetic microvascular complications.
  • Targeting PKC may offer therapeutic strategies for managing diabetes-related vascular damage.
Keywords:
diabetes mellitusdiabetic microvascular complicationsmicrovascularprotein kinase Creview

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