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Checkpoint Immunotherapy-Induced Myocarditis and Encephalitis Complicated With Complete AV Block: Not All Hope Is
Álvaro Lorente-Ros1,2, Ez-Alddin Rajjoub-Al-Mahdi1, Juan M Monteagudo Ruiz1
1Cardiology Department, Hospital Universitario Ramon y Cajal, Madrid, Spain.
Abstract:
Immune checkpoint inhibitors are associated with a myriad of autoimmune adverse events. We present a 70-year-old patient with renal-cell carcinoma treated with nivolumab/ipilimumab complicated with myocarditis and encephalitis in which gradual impairment of the His-Purkinje system progressed to complete atrioventricular block. Full recovery was achieved after treatment with corticosteroids and immunoglobulins. (Level of Difficulty: Intermediate.).
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