Related Experiment Video
Updated: Aug 29, 2025
07:55
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
14.4K
The Syncopal Sarcoma: A Rare Case of Primary Cardiac Synovial Sarcoma
Adam J Eqbal1, Laura Goodliffe2, Hassan Masoom2
1Division of Cardiac Surgery, McMaster University, Hamilton, Ontario, Canada.
JACC. Case Reports
|September 5, 2022
Insights
Primary cardiac synovial sarcoma is an extremely rare tumor. This case highlights a large intracardiac tumor causing syncope and obstructive shock in a young adult.
Area of Science:
- Cardiovascular Medicine
- Oncology
Background:
- Primary cardiac tumors are rare, with synovial sarcomas accounting for less than 1% of these neoplasms.
- Synovial sarcoma is a soft tissue sarcoma that rarely originates in the heart.
Observation:
- A 19-year-old male presented with syncope and dynamic obstructive shock.
- A large, right-sided intracardiac tumor was identified as the cause of the patient's symptoms.
Findings:
- The intracardiac mass was diagnosed as a primary cardiac synovial sarcoma.
- The tumor's size and location led to significant hemodynamic compromise.
Implications:
- This case underscores the importance of considering rare cardiac tumors in the differential diagnosis of unexplained syncope and shock.
- Early diagnosis and management are crucial for patients with primary cardiac synovial sarcoma due to its potential for rapid progression and poor prognosis.
Abstract:
Primary cardiac synovial sarcomas are very rare, representing <1% of all primary cardiac tumors. We report the case of a 19-year-old man with syncope and dynamic obstructive shock caused by a large right-sided intracardiac tumor. (Level of Difficulty: Beginner .).
Related Concept Videos
01:03Rous Sarcoma Virus (RSV) and Cancer
5.3K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.3K
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
38
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
38
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
46
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
46
01:22Pericarditis I: Introduction
18
Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
18
01:25Cardiomyopathy I: Introduction and Classification
42
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
42
01:21Myocarditis I: Introduction
23
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
23