Hepatitis of unknown origin in children: Updated evidence and concise review

The rapid emergence of severe acute hepatitis across several European countries and several geographical regions in the United States has created panic among health institutions, local authorities, governmental organizations and regulatory bodies. Early reporting, stringent surveillance and supportive care can temporarily help tackle this crisis. However, definitive containment measures and management require characterization of the clinical spectrum, epidemiological assessment and extensive investigations. Furthermore, a sound management strategy requires randomized trials to explore the treatment options.