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Related Experiment Videos

Drug-induced esophageal strictures.

L Bonavina, T R DeMeester, L McChesney

    Annals of Surgery
    |August 1, 1987
    PubMed
    Summary

    Drug-induced esophageal strictures are common and often misdiagnosed as reflux. Proper diagnosis involves considering medication history and esophageal pH monitoring, with treatment ranging from dilation to surgery.

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    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Pathology

    Background:

    • Benign esophageal strictures can have various etiologies.
    • Distinguishing between different causes is crucial for effective treatment.

    Purpose of the Study:

    • To investigate the incidence and characteristics of drug-induced esophageal strictures.
    • To differentiate drug-induced strictures from reflux-related ones.

    Main Methods:

    • Retrospective analysis of 55 patients with benign esophageal strictures.
    • Prospective study of 18 asymptomatic volunteers on drug ingestion.
    • In vitro study on drug dissolution in saliva.

    Main Results:

    • Drug-induced lesions accounted for 20% of strictures, caused by medications like potassium chloride and tetracyclines.

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  • Five patients were misdiagnosed with reflux without 24-hour esophageal pH monitoring.
  • Esophageal lodgment of medicinal capsules was frequent, especially in the elderly.
  • In vitro studies showed rapid drug dissolution and pH changes.

    • Conclusions:

    • Drug-induced esophageal strictures are more prevalent than previously thought.
    • These strictures can mimic reflux esophagitis.
    • Diagnosis relies on medication history, stricture location, and normal esophageal acid exposure.