Related Experiment Video

Updated: Aug 29, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

712

Retraction

    Biofactors (Oxford, England)
    |September 5, 2022
    PubMed

    Insights

    This study investigated propofol's neuroprotective effects, finding it down-regulates microRNA-19a in glutamate-induced PC12 cells. However, the article was retracted due to purchased content.

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Molecular Biology

    Context:

    • Glutamate excitotoxicity is a key factor in neuronal damage.
    • Propofol is a widely used anesthetic agent with potential neuroprotective properties.
    • MicroRNAs play crucial roles in regulating gene expression and cellular functions.

    Purpose:

    • To investigate the neuroprotective mechanisms of propofol in a cellular model of excitotoxicity.
    • To examine the role of microRNA-19a in propofol-mediated neuroprotection.
    • To explore the effects of propofol on glutamate-induced PC12 cell injury.

    Summary:

    • Propofol demonstrated neuroprotective effects against glutamate-induced injury in PC12 cells.
    • The study identified that propofol down-regulates microRNA-19a expression.
    • This down-regulation of microRNA-19a was associated with the observed neuroprotective functions of propofol.

    Impact:

    • Suggests a potential therapeutic pathway for neuroprotection involving propofol and microRNA-19a modulation.
    • Highlights the complex role of microRNAs in anesthetic-induced neuroprotection.
    • This article has been retracted due to concerns about purchased content, impacting its scientific validity.

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