Related Experiment Video
Updated: Aug 29, 2025

Flow Virometry to Analyze Antigenic Spectra of Virions and Extracellular Vesicles
Published on: January 25, 2017
Charge detection mass spectrometry for the analysis of viruses and virus-like particles
Lohra M Miller1, Martin F Jarrold1
1Department of Chemistry, Indiana University, 800 E Kirkwood Ave, Bloomington 47401, Indiana.
Abstract:
Heterogeneity usually restricts conventional mass spectrometry to molecular weights less than around a megadalton. As a single-particle technique, charge detection mass spectrometry (CDMS) overcomes this limitation. In CDMS, the mass-to-charge (m/z) ratio and charge are measured simultaneously for individual ions, giving a direct mass measurement for each ion. Recent applications include the analysis of viruses, virus-like particles, vaccines, heavily glycosylated proteins, and gene therapy vectors.
Related Concept Videos
MALDI-TOF Mass Spectrometry
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Mass Spectrometry: Complex Analysis
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
High-Performance Liquid Chromatography: Types of Detectors
Mass Spectrometers

