Related Experiment Video

Updated: Aug 29, 2025

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

15.1K

Correlation between genetic polymorphisms in apolipoprotein E and atrial fibrillation

Yilian Wang1, Huankun Lou2, Minglang Wang2

  • 1Department of Cardiovascular Medicine, The First Affiliated Hospital of Soochow University, Soochow, China; Department of Cardiovascular Medicine, The Second People's Hospital of Lianyungang, Lianyungang, China.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|September 5, 2022
PubMed

Insights

Genetic variations in apolipoprotein E (ApoE) are linked to atrial fibrillation (AF). The ApoE4 genotype is a significant risk factor for AF, while ApoE3 shows a protective effect.

Area of Science:

  • Genetics
  • Cardiology
  • Molecular Biology

Background:

  • Atrial fibrillation (AF) is a common arrhythmia with complex etiology.
  • Apolipoprotein E (ApoE) plays a role in lipid metabolism and has been implicated in cardiovascular diseases.
  • Genetic polymorphisms in the APOE gene may influence the risk of developing AF.

Purpose of the Study:

  • To investigate the association between apolipoprotein E (ApoE) gene polymorphisms and the occurrence of atrial fibrillation (AF).
  • To identify specific APOE genotypes and their penetrance as risk factors for AF.

Main Methods:

  • Genotyping of APOE polymorphisms in 64 AF patients and 49 controls.
  • Comparison of clinical characteristics including age, BMI, left atrial diameter, and left ventricular ejection fraction between groups.
  • Statistical analysis, including binary logistic regression, to determine risk factors for AF.

Main Results:

  • Significant differences in age, BMI, left atrial diameter, and LVEF were observed between AF patients and controls.
  • The APOE ɛ3/ɛ3 genotype was less frequent in AF patients, while ɛ3/ɛ4 and ɛ4/ɛ4 genotypes were more frequent.
  • ApoE4 penetrance was significantly higher in the AF group, and ApoE3 penetrance was lower.
  • Age, BMI, left atrial diameter, LVEF, and ApoE4 were identified as risk factors for AF.

Conclusions:

  • APOE gene polymorphisms significantly impact the occurrence of atrial fibrillation.
  • The APOE4 genotype is associated with an increased risk of AF, suggesting it is an AF-sensitive phenotype.
  • Further research into the mechanisms linking ApoE4 to AF is warranted.

Keywords:
Apolipoprotein EApolipoproteína EAtrial fibrillationFenotipo genéticoFibrilhação auricularGenetic phenotypeGenetic polymorphismInflammatory mediatorsMediadores inflamatóriosPolimorfismo genético

More Related Videos

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

10.1K
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.8K

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.0K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.7K
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
692
Correlation between ECG and Cardiac Cycle01:25

Correlation between ECG and Cardiac Cycle

The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
8.0K
Epistasis Analysis01:09

Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
5.1K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
32