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The future clinical implications of trained immunity.
Valentin Nica1, Radu A Popp1, Tania O Crișan1
1Department of Medical Genetics, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Expert Review of Clinical Immunology
|September 5, 2022
Summary
Trained immunity (TI) is a long-term innate immune response modulation. This review covers TI
Area of Science:
- Immunology
- Innate Immunity
- Trained Immunity
Background:
- Trained immunity (TI) involves long-term innate immune response modulation.
- It stems from prior exposure to microbes, microbial ligands, or endogenous substances.
- Metabolic and epigenetic reprogramming enhances monocyte, macrophage, and neutrophil responses.
Purpose of the Study:
- Review current understanding of trained immunity.
- Discuss potential clinical implications of TI.
- Explore TI's role in disease and therapeutic development.
Main Methods:
- Literature review of trained immunity research.
- Analysis of evidence linking TI to various pathologies.
- Discussion of emerging TI-based therapies.
Main Results:
- TI mechanisms are linked to diverse immune-mediated pathologies.
- Progress in TI research facilitates clinical investigation.
- TI shows potential for novel clinical tools.
Conclusions:
- Trained immunity represents a significant advancement in immunology.
- TI has broad implications across infectious, autoimmune, and oncological diseases.
- Further research may translate TI into improved clinical care standards.
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