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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
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Recent Advancements in CNS Acting Drugs: A Step Towards End of Illness

Md Noushad Javed1, Faheem Hyder Pottoo2, Mohd Javed Naim3

  • 1School of Medical and Allied Sciences, K.R. Mangalam University, Sohna Road, Gurgaon, Haryana-122103, India.

CNS & Neurological Disorders Drug Targets
|September 5, 2022
PubMed

Insights

Neurodegenerative diseases like Alzheimer's and Parkinson's stem from neuronal cell damage. This editorial explores new treatments and brain-targeted delivery systems to combat these conditions.

Area of Science:

  • Neuroscience
  • Pathology
  • Pharmacology

Background:

  • Neuronal cell degeneration underlies neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD).
  • Pathogenesis involves oxidative stress, mitochondrial dysfunction, excitotoxicity, nitric oxide toxicity, and neuro-inflammation.
  • These conditions disproportionately affect aging populations.

Discussion:

  • Complex mechanisms driving neurodegeneration are examined.
  • Challenges in developing effective neurotherapeutics are highlighted.
  • Advancements in fabricating brain-targeted delivery systems are discussed.

Key Insights:

  • Understanding multifactorial pathogenesis is crucial for therapeutic development.
  • Targeted drug delivery to the brain remains a significant hurdle.
  • Interdisciplinary approaches are advancing neurotherapeutics.

Outlook:

  • Future neurotherapeutics will likely integrate novel drug discovery with advanced delivery systems.
  • Focus on mitigating oxidative stress and neuro-inflammation is key.
  • Personalized medicine approaches may emerge for neurodegenerative diseases.

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