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Isolated Hepatic Sarcoidosis: A Case Report and Literature Review
S C Egboh1,2, E Ray-Offor1,3, C C Obiorah4
1Digestive Disease Unit, Oak Endoscopy Centre, Port Harcourt, Rivers State.
West African Journal of Medicine
|September 5, 2022
Summary
This case report details isolated hepatic sarcoidosis, a rare condition in African literature. Early diagnosis is challenging due to the lack of specific tests, potentially leading to underreporting.
Area of Science:
- Gastroenterology
- Hepatology
- Immunology
Background:
- Sarcoidosis is a multi-systemic disease characterized by non-caseating granulomas, often affecting the lungs.
- Isolated hepatic sarcoidosis, while rare, is a recognized manifestation of the disorder.
Observation:
- A hypertensive and diabetic patient presented with abdominal pain and fatigue.
- The patient exhibited hepatomegaly with a liver nodule on CT scan and elevated liver enzymes.
Findings:
- Diagnosis of isolated hepatic sarcoidosis was confirmed via liver biopsy revealing non-caseating granulomas.
- Autoimmune studies were sero-negative, and angiotensin-converting enzyme levels were elevated.
- No evidence of sarcoidosis involvement in other organ systems was found.
Implications:
- Hepatic sarcoidosis is underreported in African literature due to diagnostic challenges.
- The lack of specific diagnostic markers necessitates comprehensive evaluation for timely diagnosis.
- Increased awareness and diagnostic protocols are crucial for managing hepatic sarcoidosis in the region.
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