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Updated: Aug 29, 2025
Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
Published on: September 14, 2017
Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury
Yufeng Xi1, Guang Yue1, Shuqiang Gao1
1Department of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Insights
Human umbilical cord blood mononuclear cells show promise for treating perinatal brain injuries like hypoxic-ischemic encephalopathy. These cells offer regenerative and anti-inflammatory benefits, demonstrating safety and efficacy in trials for children.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Pediatrics
Background:
- Perinatal brain injury is a major cause of childhood death and disability.
- Key injuries include hypoxic-ischemic encephalopathy in term infants and white matter injury in premature infants.
- Human umbilical cord blood mononuclear cells (hUCB-MCs) possess diverse regenerative capabilities.
Purpose of the Study:
- To review the therapeutic potential of hUCB-MC transplantation for perinatal brain injury.
- To highlight the biological functions of hUCB-MCs relevant to brain repair.
- To summarize findings from preclinical and clinical studies.
Main Methods:
- Review of existing literature on hUCB-MC transplantation for perinatal brain injury.
- Analysis of studies detailing the biological mechanisms of hUCB-MCs.
- Synthesis of data from animal models and human clinical trials.
Main Results:
- hUCB-MCs contain various stem and progenitor cells with regenerative properties.
- These cells exhibit nerve and vascular regeneration, anti-apoptosis, anti-inflammation, and immune modulation.
- Transplantation of hUCB-MCs has shown significant efficacy and safety in treating perinatal brain injury.
Conclusions:
- hUCB-MC transplantation is a promising therapeutic strategy for perinatal brain injury.
- The multifaceted biological functions of hUCB-MCs support their neuroprotective and regenerative effects.
- Further research and clinical application of hUCB-MC therapy are warranted.
Abstract:
Perinatal brain injury is a leading cause of death and disability in children. Hypoxic-ischemic encephalopathy in full term infants, and white matter injury in premature infants are most known brain injury in perinatal period. Human umbilical cord blood mononuclear cells contain hematopoietic stem cells, mesenchymal stem cells, endothelial progenitor cells, lymphocytes, monocytes, and so on. Human umbilical cord blood mononuclear cells have many biological functions, such as nerve and vascular regeneration, anti-apoptosis, anti-inflammation, and immune regulation. Human umbilical cord blood mononuclear cells transplantation has achieved significant efficacy and safety in animal and clinical trials for the treatment of perinatal brain injury. We will review human umbilical cord blood mononuclear cells transplantation for perinatal brain injury in this review.
