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Updated: Aug 29, 2025

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
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AIP: A double agent? The tissue-specific role of AIP as a tumour suppressor or as an oncogene

Oliver Haworth1,2, Márta Korbonits3

  • 1Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

British Journal of Cancer
|September 5, 2022
PubMed

Insights

Aryl hydrocarbon receptor-interacting protein (AIP) acts as a tumor suppressor in pituitary tumors but as an oncogene in colorectal cancer, highlighting its dual role in cancer development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Aryl hydrocarbon receptor-interacting protein (AIP) functions as a co-chaperone for heat shock proteins and nuclear receptors.
  • Germline mutations in AIP are linked to hereditary predisposition to pituitary tumors, suggesting a tumor suppressor role.

Discussion:

  • High expression of AIP correlates with tumor development and aggressive disease in colorectal cancer.
  • Previous studies indicated a similar oncogenic role for AIP in diffuse large B-cell lymphoma.
  • This suggests a context-dependent function of AIP in tumorigenesis.

Key Insights:

  • AIP exhibits paradoxical roles, acting as a tumor suppressor in some contexts and an oncogene in others.
  • The dual function of AIP challenges its simple classification and necessitates further investigation into its regulatory mechanisms.
  • Understanding AIP's opposing roles is crucial for developing targeted cancer therapies.

Outlook:

  • Further research is needed to elucidate the molecular mechanisms underlying AIP's dual function.
  • Investigating AIP's role in other cancer types may reveal broader implications for its oncogenic or tumor-suppressive activities.
  • Targeting AIP or its pathways could offer novel therapeutic strategies for specific cancers.

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